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Make It

Make It: Decarb, Infuse, Extract

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DecarbInfuseExtract

Making edibles, oils and tinctures from cannabis follows three steps: decarboxylate to activate it, infuse it into a fat or alcohol or extract to concentrate it, then dose it. Get the order right and the rest is detail. This is the map.

1. Decarboxylate

Raw cannabis makes THCA, not THC. Heat converts it, and getting the temperature and time right is the single biggest lever on strength.

2. Infuse

Decarbed cannabis goes into a fat or alcohol so you can cook with it or dose it.

3. Extract (stronger)

Concentrated extracts pull the actives out of the plant for potent oils.

Then dose and cook

Once you have an infused base, calculate the dose and put it to work.

The workflow

Decarb, then infuse or extract, then dose. Skipping or rushing decarb is the most common reason home edibles come out weak.

Continue exploring

Decarboxylation and infusion fundamentals.

Reaction Kinetics of Decarboxylation and Lipid Solubilization

Quantitative HPLC kinetics demonstrate that thermal decarboxylation of acidic THCA-A into neutral Delta-9-THC follows a first-order reaction pathway in which controlled heating between 105 °C and 120 °C achieves complete conversion while avoiding thermal oxidation to cannabinol (CBN) (Wang et al., 2016, Cannabis and Cannabinoid Research, PubMed PMID 27920944). Subsequent co-administration or infusion into dietary lipids enhances intestinal mixed-micelle solubilization and lymphatic transport of lipophilic cannabinoids (Zgair et al., 2016, American Journal of Translational Research, PubMed PMID 27648106).

Frequently Asked Questions

Why must cannabis be decarboxylated before infusing into oil or butter?

Raw cannabis flower contains acidic cannabinoids such as THCA and CBDA rather than active THC and CBD. Controlled heating removes the carboxyl group so the cannabinoids become active before lipid infusion.

Does infusing in oil at normal simmering temperatures fully decarboxylate raw flower?

No. Oil infusion typically runs at 70 C to 95 C to protect flavor and prevent scorching, which is too slow for complete THCA conversion without a prior decarboxylation step.

What is the difference between a lipid infusion and an ethanol extraction?

A lipid infusion dissolves decarboxylated cannabinoids directly into a carrier fat such as butter, coconut oil, or MCT oil, whereas a food-grade ethanol extraction (FECO/QWET) uses alcohol as a solvent that can be kept as a tincture or evaporated into a concentrated oil.

This article is for educational purposes only. Always follow local laws regarding cannabis preparation and use.

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