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CS Cannabinoid index · Altered & non-natural
Not every cannabinoid comes from the plant or the body. This index covers the “altered” cannabinoids in four groups: metabolity the body makes from THC and CBD (including the one drug tests look for), semi-synthetic cannabinoids converted in a lab from hemp (HHC, THC-O and the rest), approved and investigational pharmaceuticals, and the fully synthetic “Spice/K2” research chemicals.
Safety note. The semi-synthetic and synthetic-research-chemical rows are listed for education and harm reduction only. The Spice/K2 compounds are potent, unpredictable and have been linked to serious harm and deaths; some semi-synthetics (THC-O, HHC-O) can form a toxic gas (ketene) when heated and must never be vaped. Nothing here is a recipe: no synthesis routes, doses or sources appear on this site.
| Compound | Formula | Intoxicating? | Known for / notes | Status |
|---|---|---|---|---|
| Human metabolites — what the body makes FROM cannabinoids | ||||
| 11-Hydroxy-THC (11-OH-THC) | C21H30O3 | Yes (active) | Active THC metabolite; prominent from edibles | |
| 11-Nor-9-carboxy-THC (THC-COOH) | C21H28O4 | No | The drug-test metabolite; inactive | |
| 7-Hydroxy-cannabidiol (7-OH-CBD) | C21H30O3 | No | Major active CBD metabolite | |
| 7-Carboxy-cannabidiol (7-COOH-CBD) | C21H28O4 | No | Terminal CBD metabolite | |
| Semi-synthetic / converted — consumer “novel” cannabinoids | ||||
| Hexahydrocannabinol (HHC) | C21H32O2 | Yes | Hydrogenated THC; more oxidation-stable | |
| THC-O-acetate (THC-O) | C23H32O3 | Yes (prodrug) | INHALATION HAZARD: heating can form ketene; do not vape | |
| HHC-O-acetate (HHC-O) | C23H34O3 | Yes | Acetylated HHC; same ketene caution as THC-O | |
| Hydrogenated CBD (H4CBD) | C21H34O2 | No | Hydrogenated CBD analog | |
| Hexahydrocannabiphorol (HHCP) | C23H36O2 | Yes (potent) | Hydrogenated 7-carbon analog | |
| Pharmaceutical — approved or investigational medicines | ||||
| Dronabinol | C21H30O2 | Yes | Synthetic Delta-9-THC (Marinol/Syndros); chemo nausea, AIDS anorexia | |
| Nabilone | C24H36O3 | Yes | Synthetic THC analog (Cesamet); chemo nausea | |
| Nabiximols | – | Yes | Sativex spray (1:1 THC:CBD); MS spasticity | |
| Rimonabant | C22H21Cl3N4O | No | Anti-obesity CB1 blocker; withdrawn for psychiatric effects | |
| Dexanabinol (HU-211) | C25H38O3 | No | Non-psychotropic enantiomer; NMDA antagonist | |
| Synthetic (Spice / K2 research chemicals) — educational only | ||||
| JWH-018 | C24H23NO | Yes (potent) | First-generation ‘Spice’; potent CB1 full agonist, high harm risk | |
| JWH-073 | C23H21NO | Yes | Early Spice agonist | |
| CP-55,940 | C24H40O3 | Yes | Pfizer reference agonist; potency benchmark | |
| WIN-55,212-2 | C27H26N2O3 | Yes | Widely used lab agonist | |
| HU-210 | C25H38O3 | Yes (very potent) | ~100-800x THC potency; strictly research | |
| AM-2201 | C24H22FNO | Yes (potent) | Second-gen Spice; high harm risk | |
| 5F-MDMB-PINACA (5F-ADB) | C20H28FN3O3 | Yes (toxic) | Recent-gen; linked to deaths, severe toxicity | |
| MDMB-4en-PINACA | C21H29N3O3 | Yes (toxic) | Widely detected recent-gen agonist | |
“Forensic” status means the compound is characterised mainly through seizures and toxicology, not medical research. “Research tool” means it exists to study the receptors, not for human use.
Part of the NOIDS cannabinoids index · see also phytocannabinoids i endocannabinoids. Educational reference, not medical advice.
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