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PL Cannabinoid index · Altered & non-natural
Not every cannabinoid comes from the plant or the body. This index covers the “altered” cannabinoids in four groups: metabolieten the body makes from THC and CBD (including the one drug tests look for), semi-synthetic cannabinoids converted in a lab from hemp (HHC, THC-O and the rest), approved and investigational pharmaceuticals, and the fully synthetic “Spice/K2” research chemicals.
| Stof | Formule | Bedwelmend? | Known for / notes | Stand |
|---|---|---|---|---|
| Human metabolites — what the body makes FROM cannabinoids | ||||
| 11-Hydroxy-THC (11-OH-THC) | C21H30O3 | Yes (active) | Active THC metabolite; prominent from edibles | |
| 11-Nor-9-carboxy-THC (THC-COOH) | C21H28O4 | Nee | The drug-test metabolite; inactive | |
| 7-Hydroxy-cannabidiol (7-OH-CBD) | C21H30O3 | Nee | Major active CBD metabolite | |
| 7-Carboxy-cannabidiol (7-COOH-CBD) | C21H28O4 | Nee | Terminal CBD metabolite | |
| Semi-synthetic / converted — consumer “novel” cannabinoids | ||||
| Hexahydrocannabinol (HHC) | C21H32O2 | Ja | Hydrogenated THC; more oxidation-stable | |
| THC-O-acetate (THC-O) | C23H32O3 | Yes (prodrug) | INHALATION HAZARD: heating can form ketene; do not vape | |
| HHC-O-acetate (HHC-O) | C23H34O3 | Ja | Acetylated HHC; same ketene caution as THC-O | |
| Hydrogenated CBD (H4CBD) | C21H34O2 | Nee | Hydrogenated CBD analog | |
| Hexahydrocannabiphorol (HHCP) | C23H36O2 | Ja (potent) | Hydrogenated 7-carbon analog | |
| Pharmaceutical — approved or investigational medicines | ||||
| Dronabinol | C21H30O2 | Ja | Synthetic Delta-9-THC (Marinol/Syndros); chemo nausea, AIDS anorexia | |
| Nabilon | C24H36O3 | Ja | Synthetic THC analog (Cesamet); chemo nausea | |
| Nabiximols | – | Ja | Sativex spray (1:1 THC:CBD); MS spasticity | |
| Rimonabant | C22H21Cl3N4O | Nee | Anti-obesity CB1 blocker; withdrawn for psychiatric effects | |
| Dexanabinol (HU-211) | C25H38O3 | Nee | Non-psychotropic enantiomer; NMDA antagonist | |
| Synthetic (Spice / K2 research chemicals) — educational only | ||||
| JWH-018 | C24H23NO | Ja (potent) | First-generation ‘Spice’; potent CB1 full agonist, high harm risk | |
| JWH-073 | C23H21NO | Ja | Early Spice agonist | |
| CP-55,940 | C24H40O3 | Ja | Pfizer reference agonist; potency benchmark | |
| WIN-55,212-2 | C27H26N2O3 | Ja | Widely used lab agonist | |
| HU-210 | C25H38O3 | Ja (zeer krachtig) | ~100-800x THC potency; strictly research | |
| AM-2201 | C24H22FNO | Ja (potent) | Second-gen Spice; high harm risk | |
| 5F-MDMB-PINACA (5F-ADB) | C20H28FN3O3 | Ja (giftig) | Recent-gen; linked to deaths, severe toxicity | |
| MDMB-4en-PINACA | C21H29N3O3 | Ja (giftig) | Widely detected recent-gen agonist | |
“Forensic” status means the compound is characterised mainly through seizures and toxicology, not medical research. “Research tool” means it exists to study the receptors, not for human use.
Onderdeel van het NOIDS-cannabinoïdenoverzicht · zie ook fytocannabinoïden en endocannabinoïden. Educatieve naslag, geen medisch advies.
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